PRAC recommendations concerning codeine in children

European Medicines Agency’s Pharmacovigilance Risk Assessment Committee

PRAC (European Medicines Agency’s Pharmacovigilance Risk Assessment Committee) has recommended restrictions on the use of codeine-containing medicines for cough and cold in children because of the risk of serious side effects, including the risk of breathing problems. Codein is converted into morphine in the body. Some people convert it more fast than normály (‘ultra-rapid metabolisers’), resulting in high levels of morphine in their blood. High levels of morphine can lead to serious effects, such as breathing difficulties. To see the specific recommendetion, check the original article.


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